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李志鹏

所属单位:动物科技学院
职称:教授
研究方向:鹿类动物生物学与消化道微生物组研究
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    李志鹏,男,1984年生,博士,教授,博士生导师,主要从事鹿类动物生物学与消化道微生物组研究。主持国家自然科学基金面上项目等项目7项;近10年取得的原创性成果如下:(1)发现维生素D代谢和雄性激素受体结合基序影响鹿茸发育,神经发生通路相关基因的大量募集是鹿茸快速生长的重要分子基础,创新了鹿茸生长调控的靶点;(2)在全球首次系统报道了鹿消化道微生物发育成熟的区段化特征,鹿、牛、羊的全消化道微生物组,提供了鹿类动物消化道微生态调控的原创性基础;(3)阐明了鹿瘤胃微生物降解粗饲料的规律与微生物学机制,创新性发现了影响鹿茸产量的靶标微生物与代谢物,开拓了高效调控鹿茸生长的营养策略,创建了鹿茸增产的精氨酸调控手段。以第一或通讯作者(含共同)在Science(3篇)、Microbiome、Science Advances、Microbial Ecology、GigaScience、Environmental Microbiology Reports、Frontiers in Microbiology、Animal Feed Science and Technology等期刊发表SCI收录论文30篇。荣获吉林省自然科学学术成果二等奖,第十六届吉林省青年科技奖特别奖(共三名),入选吉林省拔尖创新人才第三层。

一、学习经历

2002/09-2007/07, 中国农业大学, 动物医学院, 学士

2010/09-2013/07, 中国农业科学院研究生院,野生动植物保护与利用,硕士

2017/09-2020/09, 南京农业大学,动物营养与饲养,博士

二、工作经历

2007/07-2013/12,中国农业科学院特产研究所,研究实习员

2014/01-2018/12,中国农业科学院特产研究所,助理研究员

2019/01-2020/08,中国农业科学院特产研究所,副研究员

2020/09-,       吉林农业大学,教授

三、承担科研项目

1. 吉林农业大学高层次人才队伍建设专项,主持

2. 国家自然科学基金面上项目,驯鹿消化道微生物影响脂肪代谢的机制研究,主持

3. 国家自然科学基金青年项目,幼龄梅花鹿瘤胃微生物定植、起源及介导的代谢表型的研究,主持

4. 吉林省自然科学基金,精氨酸在梅花鹿胃肠道代谢机制及其对产茸量的影响,主持

5. 吉林省科技公关项目,梅花鹿肉品质评价及新产品开发,2019.1至2021.12,主持人

6. 中央级基本科研业务费,中国-丹麦特种动物生物大数据挖掘与利用,主持

7. 国家重点研发计划“梅花鹿产业关键技术研究及大健康产品开发”子课题,梅花鹿精细化饲养关键技术研究,主持

8. 中国科协优秀中外青年交流计划,主持

四、奖励与荣誉

1. 2014年,中国农业科学院优秀硕士论文

2. 2015年,吉林省自然科学学术成果二等奖,鹿科动物胃肠道微生物区系研究,第1

3. 2017年,吉林市优秀青年科技专家

4. 2017年,第十二届国际基因组大会GigaScience前沿科技奖

5. 2019年,第七届吉林省拔尖创新人才第三层次

6. 2020年,第十六届吉林省青年科技奖特别奖

五、发表论文(#第一作者,*通讯作者)

1. Si H, Liu H, Nan W, Li G, Li Z*, Lou Y*: Effects of arginine supplementation on serum metabolites and the rumen bacterial community of sika deer (Cervus nippon). Frontiers in Veterinary Science, 2021:8. 7

2. Si H, Han Y, Liu H, Lou Y, Li Z*: Effects of rumen-protected arginine supplementation on the plasma amino acids and gut microbiota of sika deer (Cervus nippon). Animal Feed Science and Technology. 2021,273:114828.8

3. Xie F#, Jin W#, Si H#, Yuan Y#, …Wang M*, Qiu Q*, Li Z*, Mao S*: An integrated gene catalog and over 10,000 metagenome-assembled genomes from the gastrointestinal microbiome of ruminants. Microibome, 2021, Accepted.

4. Liu C#, Gao J#, Cui X#, Li Z#, Chen L#, Yuan Y#, Zhang,Y,…Rasmus H*, Wang W*, Huang J*, Qiu Q*: A towering genome: Experimentally validated adaptations to high blood pressure and extreme stature in the giraffe. Science Advances, 2021, 7(12): eabe9459. 10

5. Shen J#, Li Z#, Yu Z, Zhu W: Effects of dietary replacement of soybean meal with dried distillers grains with solubles on the microbiota occupying different ecological niches in the rumen of growing Hu lamb. Journal of Animal Science and Biotechnology, 2020:11:93.

6. Li Z, Wang X, Alberdi A, Deng J,Zhong Z, Si H, Zheng C, Zhou H,Wang J, Yang Y, Wright A-DG, Mao S,Zhang Z, Guan L and Li G. Comparative microbiome analysisreveals the ecological relationshipsbetween rumen methanogens,acetogens, and their hosts. Frontiers in Microbiology, 2020:11:1311.

7. Li Z, Shen J, Xu Y, Zhu W: Metagenomic analysis reveals significant differences in microbiome and metabolic profiles in the rumen of sheep fed low N diet with increased urea supplementation. FEMS Microbiology Ecology, 2020:fiaa117

8. de Jong MJ#, Li Z#, Qin Y, Quéméré E, Baker K, Wang W, Hoelzel AR: Demography and adaptation promoting evolutionary transitions in a mammalian genus that diversified during the Pleistocene. Molecular Ecololgy, 2020.

9. Li Z, Mu C, Xu Y, Shen J, Zhu W: Changes in the solid-, liquid-and epithelium-associated bacterial communities in the rumen of Hu lambs in response to dietary urea supplementation. Frontiers in Microbiology, 2020, 11:244.

10. Lin Z, Chen L, Chen X, Zhong Y, Yang Y, Xia W, Liu C, Zhu W, Wang H, Yan B et al: Biological adaptations in the Arctic cervid, the reindeer (Rangifer tarandus). Science, 2019, 364(6446):eaav6312.

11. Wang Y#, Zhang C#, Wang N#, Li Z#, Heller R#, Liu R#, Zhao Y#, Han J#, Pan X, Zheng Z et al: Genetic basis of ruminant headgear and rapid antler regeneration. Science, 2019, 364(6446):eaav6335.

12. Chen L#, Qiu Q#, Jiang Y#, Wang K#, Lin Z#, Li Z#, Bibi F, Yang Y, Wang J, Nie W et al: Large-scale ruminant genome sequencing provides insights into their evolution and distinct traits. Science, 2019, 364(6446):eaav6202.

13. Li Z, Si H, Zhang T, Nan W, Wang X, Li G: Bacterial community and metabolome shifts in the cecum and colon of captive sika deer (Cervus nippon) from birth to post weaning. FEMS Microbiolgolgy Letter, 2019, 366(4).

14. Li Z, Wang X, Zhang T, Si H, Xu C, Wright A-DG, Li G: Heterogeneous development of methanogens and the correlation with bacteria in the rumen and cecum of sika deer (Cervus nippon) during early life suggest different ecology relevance. BMC Microbiololgy, 2019, 19(1):129.

15. Qian W, Ao W, Jia C, Li Z: Bacterial colonisation of reeds and cottonseed hulls in the rumen of Tarim red deer (Cervus elaphus yarkandensis). Antonie Leeuwenhoek, 2019, 112(9):1283-1296.

16. Ren Q, Si H, Yan X, Liu C, Ding L, Long R, Li Z*, Qiu Q*. Bacterial communities in the solid, liquid, dorsal, and ventral epithelium fractions of yak (Bos grunniens) rumen. MicrobiologyOpen, 2019, 9:e963.

17. Yan XT, Yan BY, Ren QM, Dou JJ, Wang WW, Zhang JJ, Zhou JW, Long RJ, Ding LM, Han J et al: Effect of slow-release urea on the composition of ruminal bacteria and fungi communities in yak. Animal Feed Science and Technology, 2018, 244:18-27.

18. Ba H#, Li Z#, Yang Y, Li C: Development of diagnostic SNP markers to monitor hybridization between sika deer (Cervus nippon) and wapiti (Cervus elaphus). G3: Genes|Genomes|Genetics, 2018, 8(7):2173–2179.

19. Li Z, Wang X, Zhang T, Si H, Nan W, Xu C, Guan L, Wright ADG, Li G: The development of microbiota and metabolome in small intestine of sika deer (Cervus nippon) from birth to weaning. Frontiers in Microbiology, 2018, 9(4).

20. Li Z, Henderson G, Yang Y, Li G: Diversity of formyltetrahydrofolate synthetase genes in the rumens of roe deer (Capreolus pygargus) and sika deer (Cervus nippon) fed different diets. Canadian Journal of Microbiology, 2017, 63(1):11-19.

21. Li Z#, Lin Z#, Ba H#, Chen L, Yang Y, Wang K, Qiu Q, Wang W, Li G: Draft genome of the reindeer (Rangifer tarandus). GigaScience, 2017, 6(12):1-5.

22. Li Z, Wright ADG, Yang YF, Si HZ, Li GY: Unique bacteria community composition and co-occurrence in the milk of different ruminants. Scientific Reports, 2017, 7:40950.

23. Qian W#, Li Z# Ao W, Zhao G, Li G, Wu J: Bacterial community composition and fermentation in the rumen of Xinjiang brown cattle (Bos taurus), Tarim red deer (Cervus elaphus yarkandensis), and Karakul sheep (Ovis aries). Canadian Journal of Microbiology, 2017, 63(5):375-383.

24. Li Z, Wright ADG, Si HZ, Wang XX, Qian WX, Zhang ZG, Li GY: Changes in the rumen microbiome and metabolites reveal the effect of host genetics on hybrid crosses. Environmental Microbiology Reports, 2016, 8(6):1016-1023.

25. Li Z, Wright AD, Liu H, Bao K, Zhang T, Wang K, Cui X, Yang F, Zhang Z, Li G: Bacterial community composition and fermentation patterns in the rumen of sika deer (Cervus nippon) fed three different diets. Microbial Ecology, 2015, 69(2):307-318.

26. Li Z, Wright ADG, Liu H, Fan Z, Yang F, Zhang Z, Li G: Response of the rumen microbiota of sika deer (Cervus nippon) fed different concentrations of tannin rich plants. PLoS ONE, 2015, 10(5):e0123481.

27. Li Z, Zhang Z, Xu C, Zhao J, Liu H, Fan Z, Yang F, Wright ADG, Li G: Bacteria and methanogens differ along the gastrointestinal tract of Chinese roe deer (Capreolus pygargus). PLoS ONE, 2014, 9(12):e114513.

28. Li Z, Liu H, Li G, Bao K, Wang K, Xu C, Yang Y, Yang F, Wright ADG: Molecular diversity of rumen bacterial communities from tannin-rich and fiber-rich forage fed domestic Sika deer (Cervus nippon) in China. BMC Microbiology, 2013, 13(1):151.

29. Li Z, Liu H, Jin C, Cui X, Jing Y, Yang F, Li G, Wright ADG: Differences in the methanogen population exist in sika deer (Cervus nippon) fed different diets in China. Microbial Ecology, 2013, 66(4):879-888.